Publications

  1. Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model
    RGB Gerben R. Borst, Ramya Kumareswaran, Hatice Yücel, Seyda Telli, Trevor …
    Oncotarget 8 (50), 87638-87646 2017
  2. Quantitative Assessment of the Immune Microenvironment in Ovarian Cancer: A Comparison of Two Digital Image Analysis Platforms
    K Duan, R Sowamber, T McKee, A Oza, S Lheureux, B Clarke, P Shaw
    LABORATORY INVESTIGATION 97, 283A-283A 2017
  3. Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft Models
    L Zhang, DC Vines, DA Scollard, T McKee, T Komal, M Ganguly, T Do, …
    Contrast Media & Molecular Imaging 2017 2017
  4. MATE2 Expression Is Associated with Cancer Cell Response to Metformin
    S Choudhury, E Yung, M Pintille, H Muaddi, S Chaib, MT Yeung, …
    PLOS One 11 (12), e0165214 2 2016
  5. Variations in the Abundance of Lipid Biomarker Ions in Mass Spectrometry Images are Correlated to Tissue Density
    J Bilkey, A Tata, T McKee, AM Porcari, E Bluemke, M Woolman, …
    Analytical Chemistry 2 2016
  6. Thermosensitive liposomal cisplatin in combination with local hyperthermia results in tumor growth delay and changes in tumor microenvironment in xenograft mode…
    YN Dou, M Dunne, H Huang, T Mckee, MC Chang, DA Jaffray, C Allen
    Journal of Drug Targeting 24 (9), 865-877 5 2016
  7. Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay
    L Hammoud, JR Adams, AJ Loch, RC Marcellus, DE Uehling, A Aman, …
    Stem Cell Reports 7 (4), 787-801 3 2016
  8. Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution
    LJ Edgar, RN Vellanki, TD McKee, D Hedley, BG Wouters, M Nitz
    Angewandte Chemie 128 (42), 13353-13357 2 2016
  9. Concordance of Tumour Hypoxia in Resectable PDAC in Patients on the Pimo-Panc Clinical Trial and Patient Derived Xenografts Using Semi-Quantitative Image An…
    I Siddiqui, N Dhani, P Cao, J Bilkey, T McKee, T Do, J Xu, S Gallinger, …
    LABORATORY INVESTIGATION 96, 448A-448A 2016
  10. RANKL blockade prevents and treats aggressive osteosarcomas
    Y Chen, MA Di Grappa, SD Molyneux, TD McKee, P Waterhouse, …
    Science Translational Medicine 7 (317), 317ra197 16 2015
  11. A Phase 2 biomarker-enriched study of evofosfamide (TH-302) in patients with advanced melanoma.
    E McWhirter, O Hamid, B Chmielowski, RD Carvajal, DA Jaffray, B Driscoll, …
    Journal of Clinical Oncology 33 (15_suppl), TPS9089-TPS9089 1 2015
  12. A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland
    YJ Shiah, P Tharmapalan, AE Casey, PA Joshi, TD McKee, HW Jackson, …
    Stem cell reports 4 (3), 313-322 14 2015
  13. Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyro…
    PJ Belmont, P Jiang, TD McKee, T Xie, J Isaacson, NE Baryla, J Roper, …
    Science Signaling 7 (351), ra107 14 2014
  14. STTARR: a radiation treatment and multi-modal imaging facility for fast tracking novel agent development in small animal models
    I Yeung, T McKee, D Jaffray, R Hill
    Proceedings of the international conference on radiation biology: frontiers … 2014
  15. Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
    VE Zannella, A Dal Pra, H Muaddi, TD McKee, S Stapleton, J Sykes, …
    Clinical Cancer Research 19 (24), 6741-6750 79 2013
  16. Reproducibility of 18F-FAZA PET-CT mouse imaging
    D Vines, T McKee, J Mahmood, H Keller, D Jaffray
    Journal of Nuclear Medicine 54 (supplement 2), 2534-2534 1 2013
  17. Quantifying nanoparticle transport in vivo using hyperspectral imaging with a dorsal skinfold window chamber
    TD Mckee, J Chen, I Corbin, G Zheng, R Khokha
    Journal of Innovative Optical Health Sciences 5 (04), 1250023 3 2012
  18. Evaluation of 99mTc-labeled small molecule inhibitors of carbonic anhydrase (CA) for imaging hypoxia
    S Hillier, G Lu, K Maresca, J Marquis, T McKee, D Green, W Eckelman, …
    Journal of Nuclear Medicine 53 (supplement 1), 217-217 1 2012
  19. Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice
    SD Molyneux, MA Di Grappa, AG Beristain, TD McKee, DH Wai, …
    The Journal of clinical investigation 120 (9), 3310 73 2010
  20. Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload
    I Koskivirta, Z Kassiri, O Rahkonen, R Kiviranta, GY Oudit, TD McKee, …
    Journal of Biological Chemistry 285 (32), 24487-24493 61 2010
  21. In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts
    JY Perentes, TD McKee, CD Ley, H Mathiew, M Dawson, TP Padera, …
    Nature methods 6 (2), 143-145 115 2009
  22. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector
    TD McKee, P Grandi, W Mok, G Alexandrakis, N Insin, JP Zimmer, …
    Cancer research 66 (5), 2509-2513 277 2006
  23. Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line
    ZN Demou, M Awad, T McKee, JY Perentes, X Wang, LL Munn, RK Jain, …
    Cancer research 65 (13), 5674-5682 37 2005
  24. Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic…
    P Huang, TD McKee, RK Jain, D Fukumura
    Comparative medicine 55 (3), 236-243 9 2005
  25. MODIFIED MICROORGANISMS FOR ANTI-CANCER THERAPY
    N FORBES, L MUNN, D FUKUMURA, R JAIN, Y BOUCHER, W MOK, …
    WO Patent 2,005,018,332 2005
  26. Improving the Delivery and Efficacy of Molecular Medicine Via Extracellular Matrix Modulation: Insights from Intravital Microscopy
    TD McKee
    Massachusetts Institute of Technology, Biological Engineering Division 2005
  27. Modified microorganisms for anti-cancer therapy
    Y Boucher, X Breakefield, NS Forbes, D Fukumura, RK Jain, TD Mckee, …
    WO Patent App. PCT/US2004/026,219 2004
  28. Defective polymerization of fibrillar collagen promotes membrane deformability and amoeboid invasion of breast adenocarcinoma
    Y Boucher, ZN Demou, M Awad, X Wang, T McKee, LL Munn, RK Jain
    Cancer Research 64 (7 Supplement), 1164-1165 2004
  29. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors
    G Alexandrakis, EB Brown, RT Tong, TD McKee, RB Campbell, …
    Nature medicine 10 (2), 203-207 155 2004
  30. Irradiation reduces interstitial fluid transport and increases the collagen content in tumors
    CA Znati, M Rosenstein, TD McKee, E Brown, D Turner, WD Bloomer, …
    Clinical cancer research 9 (15), 5508-5513 37 2003
  31. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation
    E Brown, T McKee, E diTomaso, A Pluen, B Seed, Y Boucher, RK Jain
    Nature medicine 9 (6), 796-800 735 2003
  32. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium
    S Ramanujan, A Pluen, TD McKee, EB Brown, Y Boucher, RK Jain
    Biophysical journal 83 (3), 1650-1660 368 2002
  33. Solid stress facilitates spheroid formation: potential involvement of hyaluronan
    C Koike, TD McKee, A Pluen, S Ramanujan, K Burton, LL Munn, …
    British journal of cancer 86 (6), 947-953 66 2002
  34. Role of tumor–host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors
    A Pluen, Y Boucher, S Ramanujan, TD McKee, T Gohongi, E di Tomaso, …
    Proceedings of the National Academy of Sciences 98 (8), 4628-4633 479 2001
  35. Interstitial Diffusion of Macromolecules in Solid Tumors: Role of Interstitial Matrix
    Y Boucher, A Pluen, S Ramanujan, TD Mckee, RK Jain
    ASME-PUBLICATIONS-BED 50, 1997-98